Skip to main content

Posts

Showing posts from April, 2022

Lost My Wife To Glioblastoma: MGMT and How It Affects Treatment

When Christina was first diagnosed with Glioblastoma (GBM) in February 2020 our lives went upside down.  The threat of losing my wife to cancer prematurely became a disturbing reality.   The emotions that my darling and I experienced were confused and disorganized; we were unable to think clearly. The first thought we had was to learn as much as we could about this cancer.  After the first few days information was pouring in and it was difficult to digest all at once because it was so much as diverse.  The most terrifying discovery was that GBM is the most common primary malignant brain tumor in adults and it has an exceedingly low median overall survival of only 15 months(1). Biopsy and tumor debulking with postoperative adjuvant radiotherapy and chemotherapy with alkylating agents, in the case of Christina, temozolomide(TMZ), are the most commonly carried out treatment. Towards the end of her life, she was also treated with bevacizumab, a monoclonal antibody used as anti-angiogenic t