Can Glycosylated Antitumor Ether Lipid be used to treat GBM? ChatGPT said: Great question. Let's break it down clearly and carefully.  Glycosylated Antitumor Ether Lipids (GAELs)  are a class of synthetic lipid-based molecules designed to have anticancer properties. They are derivatives of antitumor ether lipids (AELs) , with added sugar moieties (glycosylation) to improve selectivity, solubility, and reduce toxicity.  Use of GAELs in GBM (Glioblastoma Multiforme):  1. Research Evidence:    Direct studies on GAELs and GBM are limited.    There is preclinical evidence  that antitumor ether lipids  (especially compounds like edelfosine  or miltefosine ) have activity against glioblastoma cells in vitro .    Glycosylated variants  of these compounds (GAELs) have shown antitumor activity  in other cancers, such as leukemia, melanoma, and breast cancer, but direct clinical studies on GBM are sparse or non-existent as of now (2024).    2. Mechanism of Action:  GAELs are thought to:    D...