Can Glycosylated Antitumor Ether Lipid be used to treat GBM? ChatGPT said: Great question. Let's break it down clearly and carefully. Glycosylated Antitumor Ether Lipids (GAELs) are a class of synthetic lipid-based molecules designed to have anticancer properties. They are derivatives of antitumor ether lipids (AELs) , with added sugar moieties (glycosylation) to improve selectivity, solubility, and reduce toxicity. Use of GAELs in GBM (Glioblastoma Multiforme): 1. Research Evidence: Direct studies on GAELs and GBM are limited. There is preclinical evidence that antitumor ether lipids (especially compounds like edelfosine or miltefosine ) have activity against glioblastoma cells in vitro . Glycosylated variants of these compounds (GAELs) have shown antitumor activity in other cancers, such as leukemia, melanoma, and breast cancer, but direct clinical studies on GBM are sparse or non-existent as of now (2024). 2. Mechanism of Action: GAELs are thought to: D...