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GAELs for GBM Treatment

 Can Glycosylated Antitumor Ether Lipid be used to treat GBM? ChatGPT said: Great question. Let's break it down clearly and carefully. Glycosylated Antitumor Ether Lipids (GAELs) are a class of synthetic lipid-based molecules designed to have anticancer properties. They are derivatives of antitumor ether lipids (AELs) , with added sugar moieties (glycosylation) to improve selectivity, solubility, and reduce toxicity. Use of GAELs in GBM (Glioblastoma Multiforme): 1. Research Evidence: Direct studies on GAELs and GBM are limited. There is preclinical evidence that antitumor ether lipids (especially compounds like edelfosine or miltefosine ) have activity against glioblastoma cells in vitro . Glycosylated variants of these compounds (GAELs) have shown antitumor activity in other cancers, such as leukemia, melanoma, and breast cancer, but direct clinical studies on GBM are sparse or non-existent as of now (2024). 2. Mechanism of Action: GAELs are thought to: D...
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A Thousand Pictures, Three Remain

A thousand pictures, scattered wide, Moments frozen, side by side. Laughter, sunsets, faces bright, Fleeting echoes caught in light. Yet in the haze of time's embrace, Only three still hold their place. One of love, so pure, so true, One of loss, a tear in blue. One of hope—a flame so small, Yet the dearest one of all. Yes, you have guessed right; I was not having a perfect moment then I discovered these pictures in my Blogger picture drive; fresh air from the past.  I will sleep with a smile tonight.
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Lurking Poison II

  I never dared to continue with this story .   My feelings for what happened are unchanged.  My resentment is also there, however, as time passes I learn that those feelings will not lead me anywhere.  We do not forget but choose to survive and continue.  Sometimes I go for a walk and think about those days and it still hurts. It is better to close this chapter and leave it as is, that way this monster will not catch me again.
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It's been a Long Time Since I've Seen Her

To our daughters; I learned so much from your mother!  She was my lover and my bosom friend.    The summer of 1992 was running in earnest and Mom and I were escaping every day to many different places around the mainland.  We were having the time of our lives!  At the end of the summer, I did not have a penny left but was the happiest man alive! Mom had a white 1989 Chevrolet Cavalier station wagon.  Her car smelled like a wet dog, Sam, her dog, was the main passenger before she met me.  That car would break down every 100 kilometers or so and would run out of gas as soon as the gas red light went on, and guess who had to push; your Dad!  But, we were like peas and carrots and as happy as they came. You always tell me - " Dad, you know strange old words and expressions no one uses these days! " Your mom is responsible for that! I learned what a "Sea Shanty" is in that white Cavalier listening to CBC radio.   The station had a show on sai...
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Settling the Score

Today, completely out of the blue, I remembered a story from my childhood.  In my neighborhood, there was a child whom everyone called "Buchee".  This fellow was a lot older than me, about three or four years older.  Therefore, if I recall correctly he must have been a young teenager when these events happened. Buchee lived near my maternal grandparents, who lived two blocks from where I lived.  Every time I visited my grandparents I had to walk by Buchee's house and we would exchange hellos and sometimes we would tease each other lightly, nothing offensive.  I would visit my grandparents daily after school therefore I would walk the distance every day and most days Buchee and I would exchange friendly words.   One evening a group of children, including me, were playing cards on the sidewalk, a few doors from my grandparents.  These games could be very competitive and the currency used at that time was crystal marbles.  At some point, the sta...
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Dear Love

  Dear Love, Forgive me, it has been a while since I have written to you.  It is not for the lack of news; home is buzzing with events typical of growing pains and gaining experience.  For me, it is just about missing your hands, warm body, your words; missing planning something to do together.  I must admit, you always had the best ideas. Recently I became a Master Chef , but not the kind of chef popular among all ages; oh, no!  I cook your dishes, daring, adventurous, and full of flavor!  I set the table and see you on your chair , right opposite to mine displaying my favorite smile, approving the dinner.   I remember when you made Spaghetti Tomato Bassilic for the first time.  You thought that I was not going to like it.  Boy, were you in for a surprise!  It became my favorite dinner!  You made it for me.  What a treat! Oh, Christina, you were the wife I always wanted to have!  The fact that we found each other mad...
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Where is the Wisdom

  During the past few months, I have written stories about my family, things we have done together, and how I feel about Christina not being here physically.  While I think about all of these stories, events, and feelings, it becomes evident, to me, that there is a great deal of randomness in our lives; there is no master plan.   Of course, we all have goals and fantasies, things we would like to do.  To attempt to accomplish these things we create paths in our minds, others write them in steps or priorities.  These paths help us stay focused on these goals, but what I have experienced is that the actual execution of these steps takes place in an  ether we live in not in isolation.  Naturally, the path to our goals is heavily modulated by the environment we are in; by our lives. Christina and I had many plans. A recurring fantasy was to have a long holiday with her.  We often talked about going to a warm place and simmering our bodies on...
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